Stronger inhibition of gastric acid secretion by lafutidine, a novel H2 receptor antagonist, than by the proton pump inhibitor lansoprazole

被引：4

作者：

Hatsushi Yamagishi

Tomoyuki Koike

Shuichi Ohara

Toru Horii

Ryousuke Kikuchi

Shigeyuki Kobayashi

Yasuhiko Abe

Katsunori Iijima

Akira Imatani

Kaori Suzuki

Takanori Hishinuma

Junichi Goto

Tooru Shimosegawa

机构：

[1] Division of Clinical Pharmacy Tohoku University Graduate School of Pharmaceutical Sciences Sendai 9808574 Japan

[2] Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai 9808574 Japan

[3] Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai 9808574 Japan

[4] Division of Pharmacotherapy Tohoku University Graduate School of Pharmaceutical Sciences and Department of Pharmaceutical Sciences Tohoku University Hospital Sendai 9808574 Japan

来源：

World Journal of Gastroenterology | 2008年 / 15期

关键词：

Lafutidine; Lansoprazole; H2 receptor antagonists; Proton pump inhibitors; Antisecretory activity;

D O I：

暂无

中图分类号：

R571 [食管疾病];

学科分类号：

1002 ; 100201 ;

摘要：

AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. RESULTS: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. CONCLUSION: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidinethan by LPZ.

引用

页码：2406 / 2410

页数：5

共 6 条

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