Recent developments in protein modeling and design

被引：0

作者：

来鲁华

徐筱杰

唐有祺

机构：

[1] State Key Laboratory for Structural Chemistry of Unstable and Stable Species

[2] Department of Chemistry

[3] Peking University

[4] Beijing

[5] China

来源：

Progress in Natural Science | 1995年 / 01期

关键词：

protein modeling; molecular design; protein backbone structure; phelctic tree; rational drug design;

D O I：

暂无

中图分类号：

Q51 [蛋白质];

学科分类号：

071010 ; 081704 ;

摘要：

<正> 1 Protein modeling and molecular design The chemical reacitivity and biological activity of proteins are mainly determined by their three-dimensional structures. So a study on them is essential to protein engineering.The X-ray crystallography is one of the most efficient methods for determining the protein structures, but it encounters difficulty in crystal growth. The recently developed multi-dimensional NMR can be directly used for determining protein structures in solu-tion, but it needs relatively large quantity of high-purity samples and requires the

引用

页码：3 / 7

页数：5

共 8 条

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[3]

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[4]

Luo Yu et al. Protein Engineering . 1992

[5]

Yuan Xuemei et al.Chinese Chem. Lett . 1993

[6]

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[7]

Sutcliffe,M. J. et al. Protein Engineering . 1987

[8]

Lai Lu-hua,Xu Xiao-jie et al.Science in China, Ser. B . 1992

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