Propofol promotes spinal cord injury repair by bone marrow mesenchymal stem cell transplantation

被引：0

作者：

Yajing Zhou ^{[1
]}

Jianmin Liu ^{[2
]}

Shuming Wei ^{[3
]}

Yunhao Zhang ^{[1
]}

Zhenhua Qu ^{[1
]}

Shubo Chen ^{[4
]}

机构：

[1] Department of Anesthesiology, Xingtai People’s Hospital, Hebei Medical University

[2] Department of Orthopedic Trauma, Xingtai People’s Hospital, Hebei Medical University

[3] Department of Anesthesiology, Third Hospital of Hebei Medical University

[4] Department of Urinary Surgery, Xingtai People’s Hospital, Hebei Medical University

来源：

Neural Regeneration Research | 2015年 / 10卷 / 08期

关键词：

nerve regeneration; bone marrow mesenchymal stem cells; stem cell transplantation; propofol; spinal cord injury; repair; neuroprotection; anesthesia; neural regeneration;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Propofol is a neuroprotective anesthetic. Whether propofol can promote spinal cord injury repair by bone marrow mesenchymal stem cells remains poorly understood. We used rats to investigate spinal cord injury repair using bone marrow mesenchymal stem cell transplantation combined with propofol administration via the tail vein. Rat spinal cord injury was clearly alleviated; a large number of newborn non-myelinated and myelinated nerve fibers appeared in the spinal cord, the numbers of CM-Dil-labeled bone marrow mesenchymal stem cells and fluorogold-labeled nerve fibers were increased and hindlimb motor function of spinal cord-injured rats was markedly improved. These improvements were more prominent in rats subjected to bone marrow mesenchymal cell transplantation combined with propofol administration than in rats receiving monotherapy. These results indicate that propofol can enhance the therapeutic effects of bone marrow mesenchymal stem cell transplantation on spinal cord injury in rats.

引用

页码：1305 / 1311

页数：7

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