A new multifunctional polymer:Synthesis and characterization of mPEG-b-PAA-grafted chitosan copolymer

被引：4
|
作者：
刘承斌 [1 ,2 ]
王小见 [2 ]
刘荣华 [1 ,2 ]
吴育林 [2 ]
罗胜联 [1 ,2 ]
机构：
[1] State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University
[2] College of Chemistry and Chemical Engineering,Hunan University
来源：
Journal of Central South University of Technology | 2010年 / 17卷 / 05期
基金：
中国国家自然科学基金; 美国国家科学基金会;
关键词：
chitosan; polyacrylic acid (PAA); polyethylene glycol (PEG); multifunction polymer; synthesis; characterization;
D O I：
暂无
中图分类号：
O631.3 [高聚物的化学性质];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A new multifunctional mPEG-b-PAA-grafted chitosan copolymer possessing amino and carboxyl groups,mPEG-b-PAA-g-CHI(compound 6) ,was designed for a potential application in gene/drug delivery and synthesized by the methods of reversible addition-fragmentation chain transfer(RAFT) polymerization of acrylic acid(AA) and grafting reaction of a biodegradable chitosan(CHI) derivative.Completion of the reactions and characterization of the resulting compounds were demonstrated by 1 H NMR,FTIR and gel permeation chtomatography(GPC) studies.The results show that the molar ratio of amino groups to carboxyl groups in the copolymer(compound 6) is 0.41-0.59.
引用
收藏
页码：936 / 942
页数：7
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