Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas

被引：0

作者：

Toshiyuki Nakayama

Ayumi Yoshizaki

Shinji Naito

Gabit Alipov

Yuichi Yakata

Ichiro Sekine

机构：

[1] Department of Molecular Pathology Nagasaki University Graduate School of Biomedical Sciences 1-12-4 Sakamoto

[2] Division of Pathology Research Laboratory

[3] Japan

[4] Nagasaki 852-8523

[5] National Ureshino Medical Center

[6] Saga 843-0301

[7] Tissue and Histopathology Section Atomic Bomb Disease Institute

来源：

World Journal of Gastroenterology | 2006年 / 11期

关键词：

Ets-1; GISTs; Leiomyoma; Schwannoma; Immunohistochemistry; Risk category;

D O I：

暂无

中图分类号：

R735 [消化系肿瘤];

学科分类号：

100214 ;

摘要：

AIM: Gastrointestinal stromal tumors (GISTs) are rare. GISTs differ from other mesenchymal tumors of the gastrointestinal tract (e.g. leiomyomas and schwannomas). The purpose of this study was to investigate the role of Ets-1 in the growth and differentiation of GISTs. METHODS: Twenty-eight GISTs, nine leiomyomas and six schwannomas were examined by immunohistochemical staining method for Ets-1 in this study. Specimens were selected from surgical pathology archival tissues at Nagasaki University Hospital. RESULTS: Ets-1 protein was expressed in the cytoplasm of cells in all of these tumors. Immunohistochemical staining revealed that 27 GISTs (96.4%), six leiomyomas (66.7%), and five schwannomas (83.3%) were positive for Ets-1. Ets-1 expression was statistically different between GISTs and leiomyomas (P< 0.005). However, there was no correlation between Ets-1 expression and clinical risk categories. CONCLUSION: Ets-1 plays an important role in the growth and differentiation of GISTs, leiomyomas and schwannomas.

引用

页码：1743 / 1746

页数：4