New bisabolane-type phenolic sesquiterpenoids from the marine sponge Plakortis simplex

被引：1
|
作者：
WANG Jie [1 ,2 ]
LIU Li [2 ]
HONG Li-Li [2 ]
ZHAN Kai-Xuan [3 ]
LIN Zheng-Jiang [1 ]
JIAO Wei-Hua [2 ]
LIN Hou-Wen [2 ]
机构：
[1] School of Food and Pharmacy, Zhejiang Ocean University
[2] Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
[3] Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine
来源：
Chinese Journal of Natural Medicines | 2021年 / 19卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Marine sponge; Plakortis simplex; Sesquiterpene phenols; Plakordiols;
D O I：
暂无
中图分类号：
R284 [中药化学];
学科分类号：
1008 ;
摘要：
Six new bisabolane-type phenolic sesquiterpenoids, including plakordiols A-D(1-4),(7 R, 10 R)-hydroxycurcudiol(5)and(7 R, 10 S)-hydroxycurcudiol(6) were isolated from the marine sponge Plakortis simplex collected from the South China Sea. Their structures were determined based on extensive analysis of spectroscopic data. Their configurations were assigned by coupling constant analysis, NOESY correlations, and the modified Mosher’s method. Furthermore, their cytotoxic and antibacterial activities were evaluated.
引用
收藏
页码：626 / 631
页数：6
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