Withania somnifera: a pre-clinical study on neuroregenerative therapy for stroke

被引：0

作者：

Aparna Raghavan ^{[1
]}

Zahoor A Shah ^{[2
]}

机构：

[1] Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo

[2] Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo

来源：

Neural Regeneration Research | 2015年 / 10卷 / 02期

关键词：

Withania somnifera; a pre-clinical study on neuroregenerative therapy for stroke; MCAO; PARP; WS;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

<正>Stroke management exerts insurmountable societal and economic burden on the patient as well as their caregivers.In the year 2010 alone,the direct and indirect costs of stroke care amounted to 36.5 billion dollars(Go et al.2014).Despite concentrated efforts to develop a safe,ef-

引用

页码：183 / 185

页数：3

共 10 条

[1]

Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor. Acevedo Lisette M,Barillas Samuel,Weis Sara M,G?thert Joachim R,Cheresh David A. Blood . 2008

[2]

Toward Wisdom From Failure: Lessons From Neuroprotective Stroke Trials and New Therapeutic Directions[J] . David J. Gladstone,Sandra E. Black,Antoine M. Hakim. &nbspStroke: Journal of the American Heart Association . 2002 (8)

[3] Themes and strategies for studying the biology of stroke recovery in the poststroke epoch [J].

Carmichael, S. Thomas .

STROKE, 2008, 39 (04) :1380-1388

[4]

Withania somnifera : An Indian ginseng[J] . S.K. Kulkarni,Ashish Dhir. &nbspProgress in Neuropsychopharmacology & Biological Psychiatry . 2007 (5)

[5]

Heart disease and stroke statistics--2014 update:a report from the American Heart Association. Go AS,Mozaffarian D,Roger VL,Benjamin EJ,Berry JD,Blaha MJ,Dai S,Ford ES,Fox CS,Franco S,Fullerton HJ,Gillespie C,Hailpern SM,Heit JA,Howard VJ,Huffman MD,Judd SE,Kissela BM,Kittner SJ,Lackland DT,Lichtman JH,Lisabeth LD,Mackey RH,Magid DJ,Marcus GM,Marel. Circulation . 2014

[6]

Withania somnifera improves ischemic stroke outcomes by attenuating PARP1-AIF-mediatedcaspase-independent apoptosis. Raghavan A,Shah ZA. Molecular Neurobiology . 2014

[7]

Acute stroke therapy with tissue plasminogen activator (tPA) since it was approved by the U.S. Food and Drug Administration (FDA). Zivin Justin A. Annals of Neurology . 2009

[8]

Wnt signaling enhances neurogenesis and improves neurological function after focal ischemic injury. Shruster Adi,Ben-Zur Tali,Melamed Eldad,Offen Daniel. PloS one . 2012

[9]

Role and therapeutic potential of VEGF in the nervous system. Ruiz de Almodovar Carmen,Lambrechts Diether,Mazzone Massimiliano,Carmeliet Peter. Physiological Reviews . 2009

[10]

Angiogenesis, Neurogenesis and Neuroplasticity in Ischemic Stroke. M. Angels Font,Adria Arboix,Jerzy Krupinski. Current Cardiology Reviews . 2010

← 1 →