Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop

被引：0
作者：
Ling-ling Shen [1 ]
Ming-liang Jiang [1 ,2 ]
Si-si Liu [1 ,2 ]
Min-chun Cai [1 ]
Zhong-qiu Hong [1 ]
Li-qing Lin [1 ,2 ]
Yan-yan Xing [1 ,2 ]
Gui-lin Chen [1 ,2 ]
Rui Pan [3 ]
Li-juan Yang [1 ,2 ]
Ying Xu [2 ]
Jun Dong [1 ,2 ]
机构：
[1] Department of Pathophysiology,Key Laboratory of the State Administration of Traditional Chinese Medicine,Medical College of Jinan University
[2] GHM Institute of CNS Regeneration,Jinan University
[3] Department of Orthopedics,First Affiliated Hospital,Medical College of Jinan University
来源：
Neural Regeneration Research | 2015年 / 10卷 / 06期
基金：
中国国家自然科学基金;
关键词：
nerve regeneration; curcumin; neurons; HIV-1; gp120; V3; loop; plasticity; HIV-associated neurocognitive disorders; output/input curve; long-term potentiation; excitatory postsynaptic potential; paired-pulse facilitation; Ca2+; synaptosome; NSFC grants; neural regeneration;
D O I：
暂无
中图分类号：
R285 [中药药理学];
学科分类号：
1008 ;
摘要：
Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca2+ concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gp120 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug.
引用
收藏
页码：925 / 931
页数：7
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