Function and regulation of Aurora/Ipllp kinase family in cell division

被引：10
作者：
Yu WEN KE ZHEN DOU JIE ZHANG XUE BIAO YAO Laboratory for Cell Dynamics School of Life Sciences University of Science and Technology of ChinaHefei China Department of Molecular and Cell Biology University of California Berkeley CA USA [1 ,230027 ,2 ,94720 ]
机构：
来源：
CellResearch | 2003年 / 02期
关键词：
Aurora (Ipllp); mitosis; and cancer;
D O I：
暂无
中图分类号：
Q26 [细胞生物化学];
学科分类号：
071009 ; 090102 ;
摘要：
<正> During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipllp family in mitosis and provides potential links between aberrant regulation of Aurora/Ipllp kinases and pathogenesis of human cancer.
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页码：69 / 81
页数：13
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