MLH1、PMS2、MSH2、MSH6的结果解读

被引：1

作者：

董水凤 ^{[1
]}

机构：

[1] 浙江省杭州市余杭区第一人民医院

来源：

中国妇幼健康研究 | 2017年 / S4期

关键词：

结直肠癌; MLH1、PMS2、MSH2、MSH6; IHC;

D O I：

暂无

中图分类号：

R735.34 [];

学科分类号：

100214 ;

摘要：

目的:探讨MLH1、PMS2、MSH2、MSH6在结直肠癌中的表达及临床意义。方法:随机选择2010年-2017年在本院诊治的结直肠癌患者500例,采用IHC方法,检测MLH1、PMS2、MSH2、MSH6在500例结直肠癌患者中的表达。结果:结直肠癌患者中错配修复蛋白的缺失率为16.2%,和肿瘤的分化、性别、年龄均无相关性。MSH1与PMS2蛋白的缺失具有相关性,MSH2和MSH6之间具有相关性。MLH1与MSH6、MSH2蛋白的缺失之间无相关性,PMS2和MSH2、MSH6之间无相关性。结论:在结直肠癌患者中错配修复蛋白MLH1、PMS2、MSH2、MSH6的缺失与患者的年龄、性别、肿瘤的分化无相关性,MSH1与PMS2蛋白的缺失具有相关性,MSH2和MSH6之间具有相关性。

引用

页码：452 / 453

页数：2

共 7 条

[1] Identification of new genetic alterations in MLH1, MSH2 and MSH6 using IHC and HRM analysis in Lynch syndrome-suspected patients. A Mazurek,A Fiszer-Kierzkowska,M Budryk. Hereditary Cancer in Clinical Practice . 2012
[2] Dominant mutations in S.cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. Smith CE,Mendillo ML,Bowen N,Hombauer H,Campbell CS,Desai A,Putnam CD,Kolodner RD. PLoS Genet . 2013
[3] Isolated Loss of PMS2Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients. Kato A,Sato N,Sugawara T,et al. American Journal of Surgical Pathology . 2016
[4] DNA mismatch repair abnormalities in acinar cell carcinoma of the pancreas:frequency and clinical significance.. Liu W,Shia J,G?nen M,et al. Pancreas . 2014
[5] Significant frequency of MSH2/MSH6 abnormality in ovarian endometrioid carcinoma supports histotype-specific Lynch syndrome screening in ovarian carcinomas. Rambau PF,Duggan MA,Ghatage P,et al. Histopathology . 2016
[6] Origin of MLH1 , MSH2 , MSH6 and PMS2 mutations can help inform long‐term care strategies for patients with colorectal and endometrial cancer[J] . J. W. Hickmott. &nbspClin Genet . 2015 (6)
[7] Subcellular protein expression models for microsatellite instability in colorectal adenocarcinoma tissue images. Kovacheva V N,Rajpoot N M. BMC Bioinformatics . 2016

← 1 →