Preservation of non-heart-beating donor livers in extracorporeal liver perfusion and histidine-trytophan-ketoglutarate solution

被引：0

作者：

Jin Gong

机构：

来源：

World Journal of Gastroenterology | 2008年 / 15期

基金：

国家高技术研究发展计划(863计划);

关键词：

Extracorporeal liver perfusion; Histidine- Trytophan-Ketoglutarate solution; Non-heart-beating donor; Preservation;

D O I：

暂无

中图分类号：

R657.3 [肝及肝管];

学科分类号：

1002 ; 100210 ;

摘要：

AIM: To compare the preservation of non-heart- beating donor (NHBD) livers in cold histidine-trytophan- ketoglutarate (HTK) solution and extracorporeal liver perfusion (ECLP). METHODS: Livers harvested from health pigs were stored for 10 h in cold HTK solution (group A, n = 4) or perfused with oxygenated autologous blood at body temperature (group B, n = 4). Both groups were then tested on the circuit for 4 h. Bile production, hemodynamic parameters, hepatocyte markers and reperfusion injury of extracorporeal livers were tested in each group. Liver tissues from each group were examined at the end of reperfusion. RESULTS: At 1, 2, 3 and 4 h after reperfusion, bile production, hemodynamic parameters, hepatocyte markers and reperfusion injury of livers in group A were statistically different from those in group B (P < 0.05 or P < 0.01). CONCLUSION: ECLP is better than HTK solution to preserve NHBD livers. ECLP can assess the graft viabilitybefore liver transplantation.

引用

页码：2338 / 2342

页数：5

共 18 条

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