Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease

被引：0

作者：

Matin Ramezani ^{[1
,2
]}

Niloufar Darbandi ^{[1
]}

Fariba Khodagholi ^{[2
]}

Azam Hashemi ^{[1
]}

机构：

[1] Department of Biology,Faculty of Science,Arak University

[2] Neuroscience Research Center,School of Medicine,Shahid Beheshti University of Medical Sciences

来源：

Neural Regeneration Research | 2016年 / 11卷 / 12期

关键词：

nerve regeneration; myricetin; Alzheimer’s disease; streptozotocin; hippocampus; pyramidal neurons; CA3; region; behavioral test; neural regeneration;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

There is currently no treatment for effectively slowing the progression of Alzheimer’s disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer’s disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 m L/kg saline. Behavioral test(the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer’s disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer’s disease.

引用

页码：1976 / 1980

页数：5

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