Association of klotho protein with contrast-induced nephropathy in patients with ST elevation myocardial infarction undergoing percutaneous coronary intervention

Background Serum Klotho protein level is a novel marker for various types of renal injury. However, the association of Klotho protein with contrast-induced nephropathy(CIN) in patients with ST elevation myocardial infarction(STEMI) with percutaneous coronary intervention(PCI) is unclear. Methods According to predefined criteria, 143 STEMI patients undergoing PCI were included in this analysis. Clinical data were compared and multivariate logistic regression analysis was performed to detect the risk factors of CIN. Results24 patients were diagnosed with CIN(16.8%). Serum Klotho protein level was significant lower in the CIN group(0.35 ± 0.16 vs. 0.47 ± 0.18, P = 0.004). Multivariate logistic regression analysis showed that serum Klotho protein was independently associated with decreased risk of CIN(OR = 0.03, 95% CI: 0.00-0.57, P = 0.019).Conclusions Serum Klotho protein may be a useful marker for diagnosis of CIN in patients with STEMI undergoing PCI.