MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer

被引：0

作者：

Rui Yi ^{[1
]}

Yao Li ^{[2
]}

Fei-Liang Wang ^{[2
]}

Gang Miao ^{[2
]}

Ruo-Mei Qi ^{[1
]}

Yan-Yang Zhao ^{[1
]}

机构：

[1] the Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, Ministry of Health

[2] Department of Surgery, Beijing Hospital, Ministry of Health

来源：

World Journal of Gastrointestinal Oncology | 2016年 / 8卷 / 04期

基金：

中国国家自然科学基金;

关键词：

MicroRNA; Diagnosis; Prognosis; Colorectal cancer; Biomarkers;

D O I：

暂无

中图分类号：

R735.34 [];

学科分类号：

100214 ;

摘要：

MicroRNAs(miRNAs) are key regulators involved in various tumors. They regulate cell cycle, apoptosis and cancer stemness, metastasis and chemoresistance by controlling their target gene expressions. Here, we mainly discuss the potential uses of miR NAs in colorectal cancer(CRC) diagnosis. We also shed light on the important corresponding miR NA targets and on the major regulators of miR NAs. Furthermore, we discuss miR NA activity in assessing the prognosis and recurrence of CRC as well as in modulating responsiveness to chemotherapy. Based on the various pro-oncogenic/anti-oncogenic roles of miR NAs, the advantages of a therapeutic strategy based on the delivery of miR NA mimics are also mentioned. Together, mi RNA seems to be an excellent tool for effectively monitoring and targeting CRC.

引用

页码：330 / 340

页数：11

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