Survivin作为肿瘤生物标记的研究进展

被引:6
|
作者
杨晓亚
李振奇
王更银
机构
[1] 白求恩国际和平医院输血科
关键词
survivin; 肿瘤; 生物标记;
D O I
暂无
中图分类号
R730.4 [肿瘤诊断学];
学科分类号
摘要
Survivin是凋亡抑制蛋白家族的成员,不表达于终末分化的组织,然而在多数肿瘤组织中异常高表达。Survivin具有抑制细胞凋亡,调控细胞周期,促进细胞分化以及增强血管发生的多重作用。由于sur-vivin的复杂功能及其在肿瘤中特异性高表达的特性,其可以作为一个分子标记在肿瘤的早期诊断及判断病人预后等方面发挥重要作用。此外,survivin还与某些癌细胞的抗药性密切相关,因此survivin还可以作为预测病人对某些抗癌治疗反应的生物标记。
引用
收藏
页码:1856 / 1859
页数:4
相关论文
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