Can the detection of IgA anti-Mycoplasma pneumoniae added to IgM increase diagnostic accuracy in patients with infections of the lower respiratory airways?

被引：0

作者：

Massimo De Paschale ^{[1
]}

Teresa Cerulli ^{[1
]}

Debora Cagnin ^{[1
]}

Alessia Paganini ^{[1
]}

Maria Teresa Manco ^{[1
]}

Luisa Belvisi ^{[1
]}

Cristina Morazzoni ^{[1
]}

Laura Marinoni ^{[1
]}

Carlo Agrappi ^{[1
]}

Paola Mirri ^{[1
]}

Pierangelo Clerici ^{[1
]}

机构：

[1] Microbiology Unit, ASST-Ovest Milanese Hospital of Legnano

来源：

World Journal of Clinical Infectious Diseases | 2016年 / 04期

关键词：

Community-acquired infections; Diagnostic yield; Elderly patients; IgA; Mycoplasma pneumoniae;

D O I：

暂无

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

1002 ; 100201 ;

摘要：

AIM To evaluate the increase in diagnostic yield, by using IgA in addition to IgM, instead of IgM alone, in relation to the age of the patients.METHODS The study considered 1067 blood samples from patients with clinical signs of lower respiratory tract infections, tested for anti-Mycoplasma IgG, IgM and IgA antibody.RESULTS The increase in diagnostic yield with IgA, compared to IgM detection alone was of 3.5% with statistically significant differences between age groups（0.8% for those equal/under 50 years of age and 4.3% for those over 50）.CONCLUSION Our findings demonstrate that IgA detection lead to a twofold increase in the number of diagnoses among the older age groups, but it did not result in relevant increase among the younger age groups.

引用

页码：67 / 72

页数：6

共 36 条

[1]

The value of culture and serology for detection of Mycoplasma pneumoniae infections in the clinical laboratory in the age of molecular diagnostics[J] . Ken B. Waites. &nbspClinical Microbiology Newsletter . 2001 (16)

[2]

Prevalence of Mycoplasma pneumoniae in Subjectively Healthy Individuals1[J] . Judy Gnarpe,Annika Lundbä,ck,Bo Sundelö,f,HÅ,Kan Gnarpe. &nbspScandinavian Journal of Infectious Diseases . 1992 (2)

[3]

Detection of Specific IgM Antibodies for the Diagnosis of Mycoplasma pneumoniae Infections: A Clinical Evaluation[J] . Tomas Vikerfors,Glenn Brodin,Monica Grandien,Lotta Hirschberg,Aud Krook,Carl-Axel Pettersson. &nbspScandinavian Journal of Infectious Diseases . 1988 (6)

[4] ENZYME-LINKED IMMUNOSORBENT-ASSAY FOR DETECTION OF MYCOPLASMA-PNEUMONIAE SPECIFIC IMMUNOGLOBULIN-M [J].

HIRSCHBERG, L ;

KROOK, A ;

PETTERSSON, CA ;

VIKERFORS, T .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1988, 7 (03) :420-423

[5] Laboratory diagnosis of Mycoplasma pneumoniae infection [J].

Daxboeck, F ;

Krause, R ;

Wenisch, C .

CLINICAL MICROBIOLOGY AND INFECTION, 2003, 9 (04) :263-273

[6] Evaluation of 10 serological assays for diagnosing Mycoplasma pneumoniae infection [J].

Busson, Laurent ;

Van den Wijngaert, Sigi ;

Dahma, Hafid ;

Decolvenaer, Marc ;

Di Cesare, Lina ;

Martin, Agnes ;

Vasseur, Liesbet ;

Vandenberg, Olivier .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2013, 76 (02) :133-137

[7]

Macrolide-resistant Mycoplasma pneumoniae : characteristics of isolates and clinical aspects of community-acquired pneumonia[J] . Miyuki Morozumi,Takashi Takahashi,Kimiko Ubukata. &nbspJournal of Infection and Chemotherapy . 2010 (2)

[8]

Mycoplasma pneumoniae. The Lancet . 1991

[9]

Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections. Principi N,Esposito S,Blasi F,Allegra L. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America . 2001

[10]

Etiology of respiratory tract infection in adults in a general practice setting. Lieberman D,Shvartzman P,Lieberman D,Ben-Yaakov M,Lazarovich Z,Hoffman S,Mosckovitz R,Ohana B,Leinonen M,Luffy D,Boldur I. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology . 1998

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