TMEM16F与相关疾病的研究进展

被引：0
作者：
王婵娟
张捷
乔蕊
机构：
[1] 北京大学第三医院检验科
来源：
检验医学 | 2017年 / 32卷 / 09期
关键词：
跨膜蛋白16F; 离子通道; 磷脂翻转活性;
D O I：
暂无
中图分类号：
R363 [病理生理学];
学科分类号：
摘要：
跨膜蛋白16F(TMEM16F)又称Anoctamin(ANO)6,是在多种细胞中表达的跨膜蛋白Anoctamin家族中的一员。目前发现的TMEM16F的主要功能有:(1)钙离子(Ca2+)依赖的氯离子(Cl-)通道,参与细胞容量调节;(2)Ca2+调节的非选择性阳离子通道;(3)Ca2+依赖的磷脂翻转活性,参与凝血、细胞凋亡和骨质钙化等多个生理过程。所以在以上功能的基础上,TMEM16F基因的突变与一种罕见的遗传出血性疾病——Scott综合征密切相关。同时,TMEM16F的缺陷还会导致骨矿化障碍和细胞容量调节障碍等。文章对TMEM16F的结构及功能进行了综述,旨在阐明TMEM16F在相关疾病的发病机制、诊断和治疗方面的重要作用。
引用
收藏
页码：831 / 836
页数：6
相关论文
共 14 条
  • [1] Detection of phosphatidyl serine on activated platelets' surface by flow cytometry in whole blood: a simpler test for the diagnosis of Scott syndrome[J] . Maxime Halliez,Marc Fouassier,Nelly Robillard,Catherine Ternisien,Marianne Sigaud,Marc Trossaert,Marie‐Christine Bene.Br J Haematol . 2015 (2)
  • [2] TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets
    Fujii, Toshihiro
    Sakata, Asuka
    Nishimura, Satoshi
    Eto, Koji
    Nagata, Shigekazu
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (41) : 12800 - 12805
  • [3] Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms
    Scudieri, Paolo
    Caci, Emanuela
    Venturini, Arianna
    Sondo, Elvira
    Pianigiani, Giulia
    Marchetti, Carla
    Ravazzolo, Roberto
    Pagani, Franco
    Galietta, Luis J. V.
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2015, 593 (17): : 3829 - 3848
  • [4] Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?[J] . Karl Kunzelmann,Bernd Nilius,Grzegorz Owsianik,Rainer Schreiber,Jiraporn Ousingsawat,Lalida Sirianant,Podchanart Wanitchakool,Edouard M. Bevers,Johan W. M. Heemskerk.Pflügers Archiv - European Journal of Physiology . 2014 (3)
  • [5] The role of TMEM16A (ANO1) and TMEM16F (ANO6) in cell migration
    Jacobsen, K. S.
    Zeeberg, K.
    Sauter, D. R. P.
    Poulsen, K. A.
    Hoffmann, E. K.
    Schwab, A.
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2013, 465 (12): : 1753 - 1762
  • [6] Inactivation of anoctamin‐6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues[J] . Harald WA Ehlen,Milana Chinenkova,Markus Moser,Hans‐Markus Munter,Yvonne Krause,Stefanie Gross,Bent Brachvogel,Manuela Wuelling,Uwe Kornak,Andrea Vortkamp.J Bone Miner Res . 2013 (2)
  • [7] Functional coupling of TRPC2 cation channels and the calcium‐activated anion channels in rat thyroid cells: Implications for iodide homeostasis[J] . Tero M. Viitanen,Pramod Sukumaran,Christoffer L?f,Kid T?rnquist.J. Cell. Physiol. . 2012 (4)
  • [8] TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation
    Yang, Huanghe
    Kim, Andrew
    David, Tovo
    Palmer, Daniel
    Jin, Taihao
    Tien, Jason
    Huang, Fen
    Cheng, Tong
    Coughlin, Shaun R.
    Jan, Yuh Nung
    Jan, Lily Yeh
    [J]. CELL, 2012, 151 (01) : 111 - 122
  • [9] Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology
    Yu, Kuai
    Duran, Charity
    Qu, Zhiqiang
    Cui, Yuan-Yuan
    Hartzell, H. Criss
    [J]. CIRCULATION RESEARCH, 2012, 110 (07) : 990 - U229
  • [10] Expression and function of epithelial anoctamins
    Kunzelmann, Karl
    Schreiber, Rainer
    Kmit, Arthur
    Jantarajit, Walailak
    Martins, Joana Raquel
    Faria, Diana
    Kongsuphol, Patthara
    Ousingsawat, Jiraporn
    Tian, Yuemin
    [J]. EXPERIMENTAL PHYSIOLOGY, 2012, 97 (02) : 184 - 192
12