Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma

被引：0

作者：

Shan-Ying Wu ^{[1
,2
]}

Sheng-Hui Lan ^{[1
,2
]}

Hsiao-Sheng Liu ^{[1
,2
,3
]}

机构：

[1] Institute of Basic Medical Sciences,College of Medicine,National Cheng Kung University

[2] Department of Microbiology and Immunology,College of Medicine,National Cheng Kung University

[3] Center of Infectious Disease and Signaling Research,College of Medicine,National Cheng Kung University

来源：

World Journal of Gastroenterology | 2016年 / 01期

关键词：

Hepatitis B virus; Autophagy; Micro RNA; Hepatocellular carcinoma; Viral replication;

D O I：

暂无

中图分类号：

R512.62 []; R735.7 [肝肿瘤];

学科分类号：

100214 ; 100401 ;

摘要：

Approximately 350 million people worldwide are chronically infected by hepatitis B virus(HBV).HBV causes severe liver diseases including cirrhosis and hepatocellular carcinoma(HCC).In about 25%of affected patients,HBV infection proceeds to HCC.Therefore,the mechanisms by which HBV affects the host cell to promote viral replication and its pathogenesis have been the subject of intensive research efforts.Emerging evidence indicates that both autophagy and micro RNAs(mi RNAs)are involved in HBV replication and HBV-related hepatocarcinogenesis.In this review,we summarize how HBV induces autophagy,the role of autophagy in HBV infection,and HBV-related tumorigenesis.We further discuss the emerging roles of mi RNAs in HBV infection and how HBV affects mi RNAs biogenesis.The accumulating knowledge pertaining to autophagy and mi RNAs in HBV replication and its pathogenesis may lead to the development of novel strategies against HBV infection and HBV-related HCC tumorigenesis.

引用

页码：176 / 187

页数：12

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