Application of Joint Detection of MYO,cTnI,CK-MB,D-D and hs-CRP in Acute Myocardial Infarction

[Objective] To discuss the diagnostic value of joint detection of myoglobin( MYO),cardiac troponin I( c Tn I),creatine kinase isoenzyme MB type( CK-MB),d-dimer( D-D),hypersensitive c-reactive protein( hs-CRP) to acute myocardial infarction( AMI).[Methods]A total of 293 cases of AMI patients were selected in the People’s Hospital of Guangxi Zhuang Autonomous Region from June 2010 to December 2014,which were classified into AMI group. At the same time,136 suspected AMI patients were taken as the control group,who were finally excluded cases. MYO,CTn I,CK-MB,D-D and hs-CRP levels were detected in two groups. The detection results and diagnostic sensitivity and specificity were statistically analyzed. [Results]( 1) The five indices in AMI group enhanced significantly compared with those in control group( P < 0. 01); MYO increased obviously after 2- 6; the five indices all enhanced; MYO reduced significantly after 12- 24 h;c Tn I,D-D and hs-CRP were still at relatively high levels after 24- 48 h.( 2) MYO,CK-MB,D-D and hs-CRP levels in left main coronary artery lesion group were significantly higher than three-vessel lesion group,double-vessel lesion group,and single-vessel lesion group( P <0. 05). Among them,three-vessel lesion group and double-vessel lesion group were significantly higher than single-vessel lesion group( P <0. 05). CK-MB levels in three-vessel lesion group and two-vessel lesion group showed no statistical significance( P > 0. 05). c Tn I levels in different groups also had no statistical significance( P > 0. 05).( 3) The sensitivity and specificity of joint detection were as high as 99. 4%and 98. 3%,respectively,which were significantly higher than those of single test. [Conclusions] Joint detection of MYO,c Tn I,CK-MB,D-D and hs-CRP was helpful to enhance the diagnostic rate of AMI,and could make up for the shortage of the single test,which was a practical test method worthy of clinical application.