Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women

被引：2

作者：

Meiqun Jia ^{[1
,2
]}

Lulu Ren ^{[1
]}

Lingmin Hu ^{[1
,3
]}

Hongxia Ma ^{[1
,4
]}

Guangfu Jin ^{[1
,4
]}

Dake Li ^{[5
]}

Ni Li ^{[6
]}

Zhibin Hu ^{[1
,4
,7
]}

Dong Hang ^{[1
,4
]}

机构：

[1] Department of Epidemiology, School of Public Health, Nanjing Medical University

[2] Department of Gynecologic Oncology, the Affiliated Tumor Hospital of Nantong University (Nantong Tumor Hospital)

[3] Department of Reproduction, the Affiliated Changzhou Maternity and Child Health Care Hospital of Nanjing Medical University

[4] Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University

[5] Department of Gynecologic Oncology, Nanjing Maternity and Child Health Hospital

[6] Program Office for Cancer Screening in Urban China, National Cancer Centre/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

[7] State Key Laboratory of Reproductive Medicine, Nanjing Medical University

来源：

The Journal of Biomedical Research | 2019年 / 33卷 / 05期

关键词：

cervical cancer; variant; long noncoding RNA; HOTAIR; MALAT1;

D O I：

暂无

中图分类号：

R737.33 [子宫肿瘤];

学科分类号：

100214 ;

摘要：

Long noncoding RNA(lncRNA) HOTAIR and MALAT1 are implicated in the development of multiple cancers. Genetic variants within HOTAIR and MALAT1 may affect the gene expression, thereby modifying genetic susceptibility to cervical cancer. A case-control study was designed, including 1 486 cervical cancer patients and 1 536 healthy controls. Based on RegulomeDB database, 11 SNPs were selected and genotyped by using Sequenom's Mass ARRAY. Univariate and multivariate logistic regression models were used to calculate the odds ratio(OR) and 95% confidence interval(CI). We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer, while the C allele of rs1787666 in MALAT1 was associated with decreased risk. Compared to individuals with 0–1 unfavorable allele, those with 3–4 unfavorable alleles showed18% increased odds of having cervical cancer. Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility.

引用

页码：308 / 316

页数：9

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