具有黄嘌呤氧化酶抑制作用的天然产物之研究进展

被引：13
作者：
姜楠
张晓琳
田金英
叶菲
机构：
[1] 中国医学科学院北京协和医学院药物研究所新药作用机制研究与药效评价北京市重点实验室
来源：
药学学报 | 2021年 / 56卷 / 05期
关键词：
天然产物; 黄嘌呤氧化酶; 尿酸; 抑制作用; 高尿酸血症;
D O I：
10.16438/j.0513-4870.2020-1952
中图分类号：
R96 [药理学];
学科分类号：
100602 ; 100706 ;
摘要：
黄嘌呤氧化酶(xanthine oxidase, XOD)参与体内嘌呤的代谢,是尿酸(uric acid, UA)生成的关键酶,成为临床治疗高尿酸血症的重要靶点。抑制XOD对治疗痛风等高尿酸血症相关的疾病以及组织氧化损伤具有重要作用。本文对具有XOD抑制作用的天然产物的研究进展进行综述。
引用
收藏
页码：1229 / 1237
页数：9
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