Characterization of a Putative Filovirus Vaccine:Virus-Like Particles

被引：0

作者：

Karen A O Martins ^{[1
]}

Travis K Warren ^{[1
]}

Sina Bavari ^{[1
]}

机构：

[1] US Army Medical Research Institute of Infectious Diseases

来源：

Virologica Sinica | 2013年 / 02期

关键词：

Filovirus; Ebola; Marburg; Vaccine; Virus-like particle; Correlates of Protection;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Filoviruses are hemorrhagic fever viruses endemic to parts of Africa and the Philippines. Infection carries with it a mortality rate of up to 90% and currently there are no effective vaccines or therapeutics available to combat infection. However, the filovirus virus-like particles (VLP), which are currently under development, have been shown to be a promising vaccine candidate. They provide protection from infection in the mouse, guinea pig, and nonhuman primate models of infection, eliciting high anti-glycoprotein antibody titers and T cell responses to viral proteins. In this review, we will highlight the development of the filovirus VLP and describe the current understanding of VLP immunogenicity and correlates of protection.

引用

页码：65 / 70

页数：6

共 6 条

[1]

Filovirius vaccines[J] . Steven B. Bradfute,John M. Dye,Jr.,Sina Bavari. Human Vaccines . 2011 (6)

[2] Ebola Zaire Virus Blocks Type I Interferon Production by Exploiting the Host SUMO Modification Machinery [J].

Chang, Tsung-Hsien ;

Kubota, Toru ;

Matsuoka, Mayumi ;

Jones, Steven ;

Bradfute, Steven B. ;

Bray, Mike ;

Ozato, Keiko .

PLOS PATHOGENS, 2009, 5 (06)

[3] Ebola virus-like particle-induced activation of NF-κB and Erk signaling in human dendritic cells requires the glycoprotein mucin domain [J].

Martinez, Osvaldo ;

Valmas, Charalampos ;

Basler, Christopher F. .

VIROLOGY, 2007, 364 (02) :342-354

[4] Ebola and Marburg virus-like particles activate human myeloid dendritic cells [J].

Bosio, CM ;

Moore, BD ;

Warfield, KL ;

Ruthel, G ;

Mohamadzadeh, M ;

Aman, MJ ;

Bavari, S .

VIROLOGY, 2004, 326 (02) :280-287

[5]

Marburg virus-like particles protect guinea pigs from lethal Marburg virus infection[J] . Kelly L Warfield,Dana L Swenson,Diane L Negley,Alan L Schmaljohn,M.Javad Aman,Sina Bavari. Vaccine . 2004 (25)

[6]

Ebola virus-like particle-based vaccine protectsnonhuman primates against lethal Ebola virus challenge .2 Warfield K L,Swenson D L,Olinger G G,Kalina W V,Aman M J,Bavari S. J Infect Dis . 2007

← 1 →