Local advanced rectal cancer perforation in the midst of preoperative chemoradiotherapy:A case report and literature review

被引：0

作者：

Nobuhisa Takase ^{[1
]}

Kimihiro Yamashita ^{[1
]}

Yasuo Sumi ^{[1
]}

Hiroshi Hasegawa ^{[1
]}

Masashi Yamamoto ^{[1
]}

Shingo Kanaji ^{[1
]}

Yoshiko Matsuda ^{[1
]}

Takeru Matsuda ^{[1
]}

Taro Oshikiri ^{[1
]}

Tetsu Nakamura ^{[1
]}

Satoshi Suzuki ^{[1
]}

Yu-Ichiro Koma ^{[2
]}

Masato Komatsu ^{[3
,4
]}

Ryohei Sasaki ^{[5
]}

Yoshihiro Kakeji ^{[1
]}

机构：

[1] Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine

[2] Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine

[3] Division of Diagnostic Pathology, Department of Pathology, Kobe University Graduate School of Medicine

[4] Department of Surgery, Hyogo Cancer Center

[5] Department of Radiation Oncology, Kobe University Graduate School of Medicine

来源：

World Journal of Clinical Cases | 2017年 / 5卷 / 01期

关键词：

Local advanced rectal cancer; Preoperative chemoradiotherapy; Rectal perforation; 5-fluorouracil; Tumor necrosis;

D O I：

暂无

中图分类号：

R735.37 [];

学科分类号：

100214 ;

摘要：

Standard chemoradiotherapy(CRT) for local advanced rectal cancer(LARC) rarely induce rectal perforation. Here we report a rare case of rectal perforation in a patient with LARC in the midst of preoperative CRT. A 56-year-old male was conveyed to our hospital exhibiting general malaise. Colonoscopy and imaging tests resulted in a clinical diagnosis of LARC with direct invasion to adjacent organs and regional lymphadenopathy. Preoperative 5-fluorouracil-based CRT was started. At 25 d after the start of CRT, the patient developed a typical fever. Computed tomography revealed rectal perforation, and he underwent emergency sigmoid colostomy. At 12 d after the surgery, the remaining CRT was completed according to the original plan. The histopathological findings after radical operation revealed a wide field of tumor necrosis and fibrosis without lymph node metastasis. We share this case as important evidence for the treatment of LARC perforation in the midst of preoperative CRT.

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页码：18 / 23

页数：6

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