Advances in Pharmacological Activity of Febrifugine and Its Derivatives

被引：0

作者：

Zhiting GUO ^{[1
]}

Jianping LIANG ^{[2
]}

Ruofeng SHANG ^{[2
]}

Wenzhu GUO ^{[2
]}

Yu LIU ^{[2
]}

机构：

[1] Key Laboratory of Veterinary Pharmaceutics Discovery,Ministry of Agriculture/Key Laboratory of New Animal Drug Project,Gansu Province,Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS,Lanzhou,Gansu 730050,China

[2] Key Laboratory of Veterinary Pharmaceutics Discovery,Ministry of Agriculture/Key Laboratory of New Animal Drug Project,Gansu Province,Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS

来源：

Medicinal Plant | 2013年 / 09期

关键词：

Febrifugine; Derivatives; Pharmacological activity;

D O I：

暂无

中图分类号：

S853.7 [中兽医药物学];

学科分类号：

0906 ;

摘要：

The herbal Dichroa febrifuga Lour is the dried roots of Saxifragaceae plant species Dichroa febrifuga Lour that are endowed with the efficacies of inducing vomiting,insecticide,anti-malaria and relieving heat.It has been broadly applied for treating malaria in folk.We reviewed the advances in pharmacological activity of effective component febrifugine in Dichroa febrifuga Lour and its derivatives,and found that Dichroa febrifuga Lour has been documented effective in antitumor,anti-coccidium,anti-scar,anti-malaria,and the treatment of diabetes mellitus and osteoporosis as well.On the basis of this,we proposed to develop safe and efficient derivatives continuously by structural modification and perform immune study and their antitumor activity.

引用

页码：56 / 57

页数：2

共 27 条

[1] 常山总碱的亚急性毒性试验 [J].

郭志廷 ;

韦旭斌 ;

梁剑平 ;

郭文柱 ;

王学红 ;

尚若锋 ;

郝宝成 .

中国兽医学报, 2012, 32 (08) :1207-1211

[2]

Observation on ultrastructure of Trichomonas vaginalis in vitro of Changshan traditional Chinese Medicine. ZHAO JL,QU M,LI HL. Shandong Medical Journal . 2007

[3]

Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats[J] . Gadi Spira,Nidal Mawasi,Melia Paizi,Natali Anbinder,Olga Genina,Rosaly Alexiev,Mark Pines. &nbspJournal of Hepatology . 2002 (3)

[4]

Drug therapies for uterine fibroids: a new approach to an old problem[J] . Romana A. Nowak. &nbspDrug Discovery Today: Therapeutic Strategies . 2004 (2)

[5]

Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours[J] . M.J.A. de Jonge,H. Dumez,J. Verweij,S. Yarkoni,D. Snyder,D. Lacombe,S. Marréaud,T. Yamaguchi,C.J.A. Punt,A. van Oosterom. &nbspEuropean Journal of Cancer . 2006 (12)

[6]

Halofuginone prevents extracellular matrix deposition in diabetic nephropathy[J] . Seiya Sato,Harukiyo Kawamura,Minoru Takemoto,Yoshiro Maezawa,Masaki Fujimoto,Tatsushi Shimoyama,Masaya Koshizaka,Yuya Tsurutani,Aki Watanabe,Shiro Ueda,Karin Halevi,Yasushi Saito,Koutaro Yokote. &nbspBiochemical and Biophysical Research Communications . 2008 (2)

[7]

Dichroa febrifuga Lour. inhibits the production of IL-1β and IL-6 through blocking NF-κB, MAPK and Akt activation in macrophages[J] . Sun Young Park,Ga-young Park,Woo Shin Ko,YoungHee Kim. &nbspJournal of Ethnopharmacology . 2009 (2)

[8] Antimalarials from nature [J].

Kaur, Kirandeep ;

Jain, Meenakshi ;

Kaur, Tarandeep ;

Jain, Rahul .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (09) :3229-3256

[9] Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents [J].

Zhu, Shuren ;

Wang, Joe ;

Chandrashekar, Gudise ;

Smith, Erika ;

Liu, Xianjun ;

Zhang, Yongshen .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) :3864-3869

[10]

Febrifugine analogue compounds: Synthesis and antimalarial evaluation[J] . Shuren Zhu,Gudise Chandrashekar,Li Meng,Katie Robinson,Dipsanker Chatterji. &nbspBioorganic & Medicinal Chemistry . 2011 (2)

← 1 2 3 →