Role of nitric oxide in hepatic ischemia-reperfusion injury

被引：0

作者：

Arunotai Siriussawakul ^{[1
]}

Ahmed Zaky ^{[1
]}

John D Lang ^{[1
]}

机构：

[1] Department of Anesthesiology and Pain Medicine and the VA Puget Sound Healthcare System,the University of Washington School of Medicine

来源：

World Journal of Gastroenterology | 2010年 / 16卷 / 48期

关键词：

Nitric oxide; Liver; Ischemia-reperfusion injury; Drug delivery;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

Hepatic ischemia-reperfusion injury (IRI) occurs upon restoration of hepatic blood flow after a period of ischemia. Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IRI based on its role in decreasing oxidative stress,cytokine release,leukocyte endothelial-adhesion and hepatic apoptosis. This review will highlight the influence of endogenous NO on hepatic IRI,role of inhaled NO in ameliorating IRI,modes of delivery,donor drugs and potential side effects of exogenous NO.

引用

页码：6079 / 6086

页数：8

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