Pancreatic ductal adenocarcinoma holds unique features to form an immunosuppressive microenvironment: a narrative review

被引：0

作者：

Zhou Qiang ^{[1
,2
]}

Chen Dan ^{[1
,2
]}

Zhang Junfeng ^{[1
,2
]}

Xiang Jifeng ^{[1
,2
]}

Zhang Tao ^{[1
,2
]}

Wang Huaizhi ^{[1
,2
]}

Zhang Yanyan ^{[1
,2
]}

机构：

[1] Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, China

[2] School of Clinical Medicine, Chongqing College, University of Chinese Academy of Sciences, Chongqing, China

来源：

胰腺病学杂志（英文） | 2022年 / 05卷 / 04期

关键词：

Cancer-associated fibroblasts; Immune-checkpoint blockage; Neoadjuvant therapy; Pancreatic ductal adenocarcinoma; Tumor-infiltrating lymphocytes; Tumor microenvironment;

D O I：

暂无

中图分类号：

R735.9 [胰腺肿瘤];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is the most common type and composes about 90% of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis, which has been considered the least immunogenic cancer for decades. However, this characterization might be over-simplistic, and more sophisticated approaches are needed to develop effective treatment strategies. In this review, we aim to summarize studies involving PDAC immunity in different aspects to provide a multidimensional recognition and comprehensively understanding of the mechanisms underlying the tumor microenvironment (TME) of PDAC. A database search of peer-reviewed articles published in English between 2003 and 2022 in PubMed and the Web of Science was performed. Original articles and review articles relevant to the topic were selected. We emphasized the importance of investigating tumor-infiltrating lymphocytes (TILs) in pancreatic cancer, especially focusing on CD8+ T cells, along with indicating potential therapeutic strategies to turn the immune-cold PDACs into the immune-hot ones.

引用

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