Effects of Portulaca Oleracea on Insulin Resistance in Rats with Type 2 Diabetes Mellitus

被引：1
作者：
沈岚
陆付耳
机构：
[1] Huazhong University of Science & Technology
[2] Huazhong University of Science & Technology Wuhan (430030)
[3] Institute of Integrated Traditional & Western Medicine
[4] Tongji Hospital
[5] Tongji Medical College
来源：
Chinese Journal of Integrated Traditional and Western Medicine | 2003年 / 04期
关键词：
diabetes mellitus type 2; Portulaca olera cea; insulin resistance; lipid metabolism; free fatty acid;
D O I：
暂无
中图分类号：
R587.1 [糖尿病];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To study the effects of Portulaca oler acea, a Chinese medicinal herb, on insulin resistance in rats with type 2 diabet es mellitus (T2DM). Methods: Experimental model of T2DM was established by injection of streptozotocin (25mg/kg) and feeding with high calorie forage. The effects o f Portulaca oleracea on oral glucose tolerance, serum levels of insulin, triglyc eride, total cholesterol, high density lipoproteins cholesterol and free f atty acids, and insulin sensitivity index were all observed. Results: Portulaca oleracea could reduce the body weight, improve the impaired glucose tolerance and lipid metabolism, decrease serum free fatty acids, attenuate hyperinsulinemia and elevate insulin sensitivity. Conclusion: Portulaca oleracea could improve insulin resistance i n rats with T2DM, and the mechanism might be related to its actions in improving lipid metabolism and decreasing free fatty acids.
引用
收藏
页码：289 / 292
页数：4
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