Claudin-1 mRNA在肝细胞癌中的表达及临床意义

被引：2

作者：

张正东 ^{[1
]}

耿小平 ^{[1
]}

李晓明 ^{[2
]}

赵红川 ^{[1
]}

赵义军 ^{[1
]}

黄帆 ^{[1
]}

机构：

[1] 安徽医科大学第一附属医院肝胆外科

[2] 香港中文大学病理科

来源：

安徽医科大学学报 | 2011年 / 46卷 / 02期

关键词：

癌,肝细胞; RNA,信使;

D O I：

10.19405/j.cnki.issn1000-1492.2011.02.008

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

目的探讨肝细胞癌(HCC)中Claudin-1 mRNA的表达与临床病理因素的关系。方法采用实时荧光定量PCR(qRT-PCR)方法检测35例HCC组织及相应癌旁组织和10例正常肝组织中Claudin-1 mRNA的表达水平,并结合相关指标进行分析。结果 Claudin-1 mRNA在HCC组织中的表达明显低于癌旁组织,差异有统计学意义(P<0.05),Clau-din-1 mRNA在HCC中的表达与肿瘤大小、AFP水平、病理分期等无相关性(P>0.05)。结论 Claudin-1 mRNA的表达下调可能与HCC的发生相关。

引用

页码：131 / 134

页数：4

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METHODS, 2001, 25 (04) :402-408

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