Bridging the injured spinal cord with neural stem cells

被引：0

作者：

Jennifer N Dulin ^{[1
]}

Paul Lu ^{[1
,2
]}

机构：

[1] Department of Neurosciences, University of California

[2] Veterans Administration Medical Center

来源：

Neural Regeneration Research | 2014年 / 9卷 / 03期

关键词：

NSCs; cell; Bridging the injured spinal cord with neural stem cells; stem;

D O I：

暂无

中图分类号：

R651.2 [脊髓];

学科分类号：

1002 ; 100210 ;

摘要：

<正>Spinal cord injury(SCI)damages not only the gray matter neurons,but also the white matter axonal tracts that carry signals to and from the brain,resulting in permanent loss of function below injury.Neural stem cells(NSCs)have high therapeutic potential for reconstruction of the injured spinal cord since they can potentially form neuronal relays to bridge functional connectivity between separated spinal cord segments.This requires host axonal regeneration into and connectivity with donor neurons,and axonal growth and connectivity of donor neurons to host central nervous system(CNS)circuitry.In this mini-review,we will discuss key studies that explore novel neuronal relay formation by grafting NSCs in models of SCI,with emphasis on long-distance axonal growth and connectivity of NSCs grafted into injured spinal cord.

引用

页码：229 / 231

页数：3

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