胰高血糖素样肽1及其类似物治疗阿尔茨海默病作用机制研究进展

被引：13

作者：

唐晶 ^{[1
]}

董齐 ^{[1
]}

伊然 ^{[2
]}

机构：

[1] 哈尔滨医科大学附属第一医院神经内科

[2] 哈尔滨医科大学附属第一医院内分泌科

来源：

中国临床神经科学 | 2015年 / 23卷 / 01期

关键词：

胰高血糖素样肽1; 胰高血糖素样肽1类似物; 阿尔茨海默病; 利拉鲁肽; 艾塞那肽;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

研究发现阿尔茨海默病(AD)的许多病理特征和认知功能下降可能与脑内胰岛素抵抗有关。对AD动物模型和轻度认知功能障碍患者的脑组织进行研究,结果表明应用胰高血糖素样肽1(GLP-1)类似物如利拉鲁肽、艾塞那肽治疗后,脑内胰岛素抵抗和许多病理特征减少或是逆转。这一研究结果为GLP-1类似物对AD的潜在治疗研究提供理论基础。对GLP-1及其类似物在AD中的潜在治疗作用做一综述。

引用

页码：95 / 101

页数：7

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