Synthesis,Crystal Structure and Insecticidal Activity of N-(pyridin-2-ylmethyl)-1-phenyl-1,4,5,6,7,8-hexahydrocyclohepta[c]pyrazole-3-carboxamide

被引：1

作者：

邓希乐 ^{[1
,2
]}

周小毛 ^{[1
]}

王赞永 ^{[1
]}

芮昌辉 ^{[3
]}

杨新玲 ^{[2
]}

机构：

[1] Hunan Agriculture Biotechnology Research Institute,Hunan Academy of Agricultural Sciences

[2] Department of Applied Chemistry, College of Science,China Agricultural University

[3] Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture,Institute of Plant Protection,Chinese Academy of Agricultural Sciences

来源：

结构化学 | 2018年 / 37卷 / 04期

关键词：

synthesis; bicyclic pyrazole amide; crystal structure; insecticidal activity;

D O I：

10.14102/j.cnki.0254-5861.2011-1787

中图分类号：

TQ453 [杀虫剂];

学科分类号：

090403 ;

摘要：

The title compound N-（pyridin-2-ylmethyl）-1-phenyl-1,4,5,6,7,8-hexahydrocyclohepta[c]pyrazole-3-carboxamide 5(C21H22N4O, Mr = 346.42) has been synthesized and structurally characterized by IR, 1H NMR, 13C NMR, H RMS and single-crystal X-ray diffraction. The crystal crystallizes in monoclinic system, space group P21/n with a = 8.668（2）, b = 22.236（4）, c = 9.539（2） ?, β = 108.68（3）°, V = 1786.4（7） ?3, Z = 4, Dx = 1.288 g/cm-3, F（000） = 736, μ（Mo Ka） = 0.649 mm-1, the final R = 0.0354 and w R = 0.0933 with 3234 observed reflections with I > 2σ（I）. The benzene and pyrazole rings are nearly coplanar with a dihedral angle of 50.977（46）°. The dihedral angle between the central pyrazole and pyridine rings is 11.688（46）°. No classical hydrogen bonds were found in the molecules. Two adjacent molecules in crystal packing of compound 5 were linked by two intramolecular hydrogen-bonding interactions C（15）–H（15）···O（1） to generate a stable structure. Compound 5 had weak insecticidal activity against the diamondback moth（Plutella xylostella）, but exhibited good activity against cotton bollworm（Helicoverpa armigera）.

引用

页码：551 / 556

页数：6

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