Efficacy and safety of Sancai powder in patients with type 2 diabetes mellitus: a randomized controlled trial

被引：0

作者：

Guo Qiang ^{[1
]}

Zhang Hengyao ^{[2
]}

Li Mindian ^{[3
]}

Zhao Ziyi ^{[4
]}

Luo Yunlin ^{[5
]}

Luo Yulei ^{[6
]}

Cao Wenzhai ^{[7
]}

Zhao Huan ^{[8
]}

Zhu Ranran ^{[1
]}

Lei Xingxing ^{[1
]}

Chen Huizhen ^{[1
]}

Gan Huakui ^{[9
]}

Zuo Zhihuang ^{[10
]}

Chen Qi ^{[11
]}

Shi Cuimei ^{[12
]}

Zhang Xinli ^{[13
]}

Guo Jian ^{[14
]}

Zhong Sen ^{[15
]}

Chen Qiu ^{[16
]}

机构：

[1] School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine

[2] Department of Endocrinology, Ningxia Chinese Medicine Research Center

[3] Department of Cellular and Molecular Physiology, Section of Comparative Medicine and Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine

[4] Department of Central Laboratory, Teaching Hospital of Chengdu University of Traditional Chinese Medicine

[5] Department of Traditional Chinese Medicine,Dujiangyan Traditional Chinese Medicine Hospital

[6] Diabetes Center, The third Teaching Hospital of Chengdu University of Traditional Chinese Medicine

[7] Medical Department of Cardiology, Zigong First People's Hospital

[8] Medical Department of Neurology, Teaching Hospital of Chengdu University of Traditional Chinese Medicine

[9] Department of Endocrinology, The First People's Hospital of Neijiang

[10] Department of Endocrinology, The Central Hospital of Guangyuan

[11] Department of Endocrinology, Zizhong County Hospital of Traditional Chinese Medicine

[12] Department of Endocrinology, Hospital of traditional Chinese Medicine of Xichang

[13] Department of Endocrinology, Liangshan Hospital of Integrated Traditional and Western Medicine

[14] Department of Endocrinology, The Second People's Hospital of Leshan

[15] Medical Department of Infections, Teaching Hospital of Chengdu University of Traditional Chinese Medicine

[16] Medical Department of Endocrinology, Teaching Hospital of Chengdu University of Traditional Chinese Medicine

来源：

JournalofTraditionalChineseMedicine | 2016年 / 36卷 / 05期

关键词：

Diabetes Mellitus; Type; 2; Sancai powder; Metformin; Treatment outcome; Randomized controlled trial;

D O I：

暂无

中图分类号：

R259 [现代医学内科疾病];

学科分类号：

100506 ;

摘要：

OBJECTIVE: To assess the efficacy and safety of Sancai powder in patients with type 2 diabetes mellitus(T2DM) inadequately controlled with single oral metformin in a randomized controlled trial(RCT).METHODS: A total of 132 patients with T2 DM were enrolled in the study, who only took metformin(500-1000 mg/day) for at least three months and with inadequate glycemic control(7.0% ≤ hemoglobin A1 c ≤ 9.0%) in the past three months.The patients stopped taking metformin with lifestyle interventions for three weeks, and 105 patients qualified for the program. They were randomly divided into the Sancai powder group and the metformin group(1500 mg/day). The follow-up period was for 12 weeks. Comparisons of several variables were analyzed.RESULTS: No significant differences were found between the two groups in hemoglobin A1c(Hb A1c),fasting plasma glucose(FPG) and 2 h post-meal glucose(2h PG), although they had decreased significantly(P < 0.01). Homeostasis model assessment of beta cell function index was significantly improved in Sancai powder group(P < 0.01), and there were significant differences in the changes of homeostasis model assessment of insulin resistance and insulin sensitivity index in the two groups(P < 0.05). Sancai powder significantly reduced triglyceride level(P < 0.05), although there was no significant difference in the body weight and body mass index in the two groups.CONCLUSION: In this 12-week study, Sancai powder could significantly reduce hemoglobin A1 c,FPG and 2h PG levels, improved beta-cell function and insulin resistance of the T2 DM inadequately controlled with metformin.

引用

页码：640 / 648

页数：9

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