Human immune repertoire in hepatitis B virus infection

被引：0
|
作者：
Qiao Zhan [1 ]
Jing-Hang Xu [1 ]
Yan-Yan Yu [1 ]
Emily Lo KK [2 ]
Felicianna [2 ]
Hani El-Nezami [2 ,3 ]
Zheng Zeng [1 ]
机构：
[1] Department of Infectious Diseases, Peking University First Hospital
[2] School of Biological Sciences, University of Hong Kong
[3] Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland
来源：
World Journal of Gastroenterology | 2021年 / 27卷 / 25期
基金：
中国国家自然科学基金;
关键词：
Immune repertoire; T-cell receptor; B-cell receptor; Hepatitis B virus; Chronic viral infection; High-throughput sequencing;
D O I：
暂无
中图分类号：
R512.62 [];
学科分类号：
100401 ;
摘要：
Hepatitis B virus(HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen-induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequencing(IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine. This review summarizes the human immune repertoire analysis methodology, and the application of the IRS in the prediction of HBV infection progression, treatment, and vaccination.
引用
收藏
页码：3790 / 3801
页数：12
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