谷胱甘肽/谷胱甘肽过氧化物酶系统在微生物细胞抗氧胁迫系统中的作用

被引:21
作者
付瑞燕 [1 ]
陈坚 [2 ]
李寅 [3 ]
机构
[1] 安徽农业大学茶与食品科技学院
[2] 江南大学工业生物技术教育部重点实验室
[3] 中国科学院微生物研究所
关键词
微生物细胞; 谷胱甘肽/谷胱甘肽过氧化物酶系统; 抗氧胁迫;
D O I
10.13345/j.cjb.2007.05.021
中图分类号
Q932 [微生物细胞学];
学科分类号
071009 ;
摘要
谷胱甘肽(GSH)/谷胱甘肽过氧化物酶(GPx)系统在不同微生物细胞抵抗氧胁迫中的生理功能不尽相同。该系统在真核模式微生物酿酒酵母中是必需存在的,在维持胞内氧化还原平衡和抵抗氧胁迫中发挥主要作用。然而,在原核微生物中,该系统只是条件性的,即部分胞内存在谷胱甘肽还原酶和GPx的原核微生物,如流感嗜血杆菌和乳酸乳球菌,可通过从胞外吸收GSH,形成条件性的依赖于GSH的GPx系统,参与抵抗氧胁迫。
引用
收藏
页码:770 / 775
页数:6
相关论文
共 8 条
  • [1] Introducing glutathione biosynthetic capability into Lactococcus lactis subsp. cremoris NZ9000 improves the oxidative-stress resistance of the host[J] . Rui-Yan Fu,Roger S. Bongers,Iris I. van Swam,Jian Chen,Douwe Molenaar,Michiel Kleerebezem,Jeroen Hugenholtz,Yin Li.Metabolic Engineering . 2006 (6)
  • [2] Tolerance of the yeast Yarrowia lipolytica to oxidative stress
    Biryukova, E. N.
    Medentsev, A. G.
    Arinbasarova, A. Yu.
    Akimenko, V. K.
    [J]. MICROBIOLOGY, 2006, 75 (03) : 243 - 247
  • [3] Using Lactococcus lactis for glutathione overproduction
    Li, Y
    Hugenholtz, J
    Sybesma, W
    Abee, T
    Molenaar, D
    [J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2005, 67 (01) : 83 - 90
  • [4] A short review on the role of glutathione in the response of yeasts to nutritional, environmental, and oxidative stresses[J] . Michel Penninckx.Enzyme and Microbial Technology . 2000 (9)
  • [5] Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeast Saccharomyces cerevisiae
    Grant, CM
    Perrone, G
    Dawes, IW
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 253 (03) : 893 - 898
  • [6] Enterococcus faecalis glutathione reductase: purification, characterization and expression under normal and hyperbaric O 2 conditions[J] . Mehul P Patel,Jovita Marcinkeviciene,John S Blanchard.FEMS Microbiology Letters . 1998 (1)
  • [7] Evolution of antioxidant mechanisms: Thiol-Dependent peroxidases and thioltransferase among procaryotes[J] . Alfred R. Sundquist,Robert C. Fahey.Journal of Molecular Evolution . 1989 (5)
  • [8] Import and metabolism of glutathione by Streptococcus mutans. Sherrill C,Fahey RC. Journal of Bacteriology . 1998