嗅觉功能变化在帕金森病和血管性帕金森综合征鉴别诊断中的作用

被引:8
作者
牛建一
刘彦博
王建法
杨允东
机构
[1] 青州市人民医院
关键词
帕金森病; 血管性帕金森综合征; 嗅觉;
D O I
暂无
中图分类号
R742.5 [震颤麻痹综合征];
学科分类号
1002 ;
摘要
目的观察帕金森病(PD)和血管性帕金森综合征(VP)患者嗅觉功能的差异,探讨嗅觉检查在鉴别PD和VP中的意义。方法 PD患者39例(PD组)、VP患者25例(VP组)、健康人群40例(对照组),采用"五味试嗅液测试法"检测各组嗅觉察觉阈和嗅觉识别阈,分析嗅觉功能检查对PD和VP鉴别诊断的灵敏度和特异度。结果PD组嗅觉察觉阈、识别阈均明显高于VP组及对照组,P均<0.05;PD组未开始抗PD治疗者嗅觉察觉阈、识别阈与开始抗PD治疗者比较均无统计学差异,P>0.05。嗅觉功能检查鉴别PD、VP的灵敏度和特异度分别为87.2%和94.3%。结论 PD患者嗅觉功能明显减退,嗅觉功能检查有助于PD和VD的鉴别诊断。
引用
收藏
页码:75 / 76
页数:2
相关论文
共 11 条
[1]  
Staging of brain pathology related to sporadic Parkinson’s disease. Braak H,Del Tredici K,Rub U,et al. Neurobiology of Aging . 2003
[2]  
Differentiating vascular parkinsonism from idiopathic Parkinson’s disease: a systematic review. S Kalra,DG Grosset,HT Benamer. Movement Disorders . 2010
[3]  
Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identifi-cation test. Double KL,Rowe DB,Hayes M,et al. Archives of Neurology . 2003
[4]  
Early diagnosis of Parkinson’’s disease and initiation oftreatment. Weiner WJ. Rev Neurol Dis . 2008
[5]  
When does Parkinson diseasestart?. Savica R,Rocca W A,Ahlskog J E. Archives of Neurology . 2010
[6]  
Olfactory dysfunction,central cholinergic integrity and cognitive impairment in Parkinson’’sdisease. Bohnen NI,Müller ML,Kotagal V,et al. Brain . 2010
[7]  
Non-motor symptoms ofParkinson’’s disease:diagnosis and management. Salawu FK,Danburam A,Olokoba AB. Nigerian Journal of Medicine . 2010
[8]   嗅觉心理物理测试的现状 [J].
刘剑锋 ;
倪道凤 .
国际耳鼻咽喉头颈外科杂志, 2006, (02) :115-118
[9]  
Analysis of olfactory function and the depth of olfactory sulcus in patients with Parkinson’s disease. JY Kim,WY Lee,EJ Chung,HJ Dhong. Movement Disorders . 2007
[10]  
Evidence in favor of Braak staging of Parkinson’s disease. DW Dickson,H Uchikado,H Fujishiro,Y Tsuboi. Movement Disorders . 2010