Drug release from a coated planar matrix with a supersaturation loading in the core I——Mathematical analysis

被引：0

作者：

徐铜文

何炳林

机构：

[1] Department of Applied Chemistry

[2] University of Science and Technology of China

[3] Hefei

[4] China

[5] State Key Laboratory of Functional Polymer Materials for Adsorption and Separation

[6] Nankai University

[7] Tianjin

来源：

Progress in Natural Science | 2000年 / 10期

关键词：

coated planar matrix; controlled release; diffusion; mathematical analysis;

D O I：

暂无

中图分类号：

O171 [分析基础];

学科分类号：

0701 ; 070101 ;

摘要：

<正> A comprehensive model is proposed to accurately describe the kinetics of drug release from a coated matrix when drug loading in the core is above its saturation level. The general solutions are obtained in dimensionless form by Laplace transform, from which special cases have been derived and the results have been discussed in different variables. According to the derived equations, the concentration profiles in the core and coating were computed and illustrated for various diffusivity ratios and thickness ratios.

引用

收藏

页码：36 / 45

页数：10

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