Drug release from a coated planar matrix with a supersaturation loading in the core I——Mathematical analysis

A comprehensive model is proposed to accurately describe the kinetics of drug release from a coated matrix when drug loading in the core is above its saturation level. The general solutions are obtained in dimensionless form by Laplace transform, from which special cases have been derived and the results have been discussed in different variables. According to the derived equations, the concentration profiles in the core and coating were computed and illustrated for various diffusivity ratios and thickness ratios.