TLR4/MD2/NF-κB信号通路与疾病的研究进展

被引：26

作者：

宋瑜婷 ^{[1
]}

彭彬 ^{[2
]}

王莹 ^{[2
]}

张雪 ^{[2
]}

曹帆帆 ^{[2
]}

张登海 ^{[2
]}

机构：

[1] 宁夏医科大学上海市浦东新区公利医院研究生培养基地

[2] 海军军医大学附属公利医院中心实验室

来源：

免疫学杂志 | 2020年 / 36卷 / 07期

关键词：

细胞信号转导通路; TLR4; MD2; NF-κB; 靶向治疗;

D O I：

10.13431/j.cnki.immunol.j.20200100

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

TLR4/MD2/NF-κB是细胞内一条重要的信号通路,该通路主要参与脂多糖和软脂酸等刺激信号的识别及转导,既往认为该通路主要与感染性炎症有关;近年研究表明,它与肿瘤、自身免疫性疾病、代谢性疾病等密切相关,靶向TLR4/MD2成为治疗这些疾病的新策略。本文就TLR4/MD2/NF-κB信号通路转导及相关疾病研究进展进行阐述。

引用

页码：633 / 638

页数：6

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