铁蓄积通过干扰Wnt信号通路导致骨质疏松

被引：10

作者：

李光飞

张辉

王爱飞

曹子厚

高焱

徐又佳

机构：

[1] 苏州大学附属第二医院骨科

来源：

中华内分泌代谢杂志 | 2019年 / 35卷 / 12期

关键词：

铁蓄积; 骨质疏松; Wnt信号通路;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

取6个月龄的野生型小鼠和6个月龄的铁调素基因敲除(Hepcidin-KO)小鼠(铁蓄积模型)的股骨标本, 进行Micro-CT检测, 以Western印迹和免疫共沉淀检测Wnt信号通路中相关指标的变化。与野生型小鼠相比, Hepcidin-KO小鼠骨量明显下降, 骨组织内β-连环蛋白(β-catenin)、TCF4/TCF7L2、FOXO3a蛋白表达无明显变化, 而β-catenin蛋白与FOXO3a结合增多, 与经典Wnt通路中TCF4/TCF7L2的结合减少, 提示铁蓄积可能通过影响经典的Wnt/β-catenin信号通路影响骨形成, 进而导致骨质疏松。

引用

页码：1061 / 1062-1063-1064

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