2D NMR Studies on the Benzodiheteropine and its Cycloaddition Products

被引:0
作者
崔育新
刘晓峰
吴海涛
潘鑫复
机构
[1] 北京医科大学药学院,兰州大学化学系
关键词
苯并杂卓;二维核磁共振谱;构象;七元杂环;
D O I
暂无
中图分类号
R913 [药物物理化学];
学科分类号
1007 ;
摘要
苯并硫氮杂卓是一类具有镇静作用的合成药物,对精神病,心脏病及高血压等疾病有一定疗效。为了深入探讨其结构与药效关系,应用1H 1HCOSY,13C 1HCOSY和NOESY等2DNMR技术对苯并硫氮杂卓1及其环加成产物2~5进行了研究,对其1H、13CNMR化学位移进行了指定,并分析讨论了化合物1~5的结构特征及苯并硫氮七元杂环呈船式构象的特点,各相关质子间的偶合常数也与讨论结果相符
引用
收藏
页码:11 / 14
页数:4
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