2D NMR Studies on the Benzodiheteropine and its Cycloaddition Products

被引：0
|
作者：
崔育新
刘晓峰
吴海涛
潘鑫复
机构：
[1] 兰州大学化学系
[2] 北京医科大学药学院
来源：
Journal of Chinese Pharmaceutical Sciences | 1998年 / 04期
关键词：
苯并杂卓; 二维核磁共振谱; 构象; 七元杂环;
D O I：
暂无
中图分类号：
R913 [药物物理化学];
学科分类号：
1007 ;
摘要：
苯并硫氮杂卓是一类具有镇静作用的合成药物，对精神病，心脏病及高血压等疾病有一定疗效。为了深入探讨其结构与药效关系，应用１Ｈ１ＨＣＯＳＹ，１３Ｃ１ＨＣＯＳＹ和ＮＯＥＳＹ等２ＤＮＭＲ技术对苯并硫氮杂卓１及其环加成产物２～５进行了研究，对其１Ｈ、１３ＣＮＭＲ化学位移进行了指定，并分析讨论了化合物１～５的结构特征及苯并硫氮七元杂环呈船式构象的特点，各相关质子间的偶合常数也与讨论结果相符
引用
收藏
页码：11 / 14
页数：4
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