Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

被引：0

作者：

LIN Peng-Cheng ^{[1
]}

JI Lin-Lin ^{[2
]}

ZHONG Xiang-Jian ^{[2
]}

LI Jin-Jie ^{[2
]}

WANG Xin ^{[2
]}

SHANG Xiao-Ya ^{[2
]}

LIN Sheng ^{[3
]}

机构：

[1] College of Pharmaceutical Sciences,Qinghai University for Nationalities

[2] Beiijing Key Laboratory of Bioactive Substances and Functional Foods,Beijing Union University

[3] State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College

来源：

ChineseJournalofNaturalMedicines | 2019年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Cirsium setosum; Taraxastane-type triterpenoid; TNF-α secretion inhibitory activity; Cytotoxicity;

D O I：

暂无

中图分类号：

R284 [中药化学];

学科分类号：

1008 ;

摘要：

Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol(1) and 22α-hydroxy-20-taraxasten-30β, 30-triol(2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC50 of 2.6 and 3.8 μmol·L-1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer(A2780) and colon cancer(HCT-8) cell lines.

引用

页码：22 / 26

页数：5