Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

被引：0
|
作者：
LIN Peng-Cheng [1 ]
JI Lin-Lin [2 ]
ZHONG Xiang-Jian [2 ]
LI Jin-Jie [2 ]
WANG Xin [2 ]
SHANG Xiao-Ya [2 ]
LIN Sheng [3 ]
机构：
[1] College of Pharmaceutical Sciences,Qinghai University for Nationalities
[2] Beiijing Key Laboratory of Bioactive Substances and Functional Foods,Beijing Union University
[3] State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College
来源：
ChineseJournalofNaturalMedicines | 2019年 / 17卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cirsium setosum; Taraxastane-type triterpenoid; TNF-α secretion inhibitory activity; Cytotoxicity;
D O I：
暂无
中图分类号：
R284 [中药化学];
学科分类号：
1008 ;
摘要：
Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol(1) and 22α-hydroxy-20-taraxasten-30β, 30-triol(2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC50 of 2.6 and 3.8 μmol·L-1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer(A2780) and colon cancer(HCT-8) cell lines.
引用
收藏
页码：22 / 26
页数：5
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