Autophagy: a double-edged sword for neuronal survival after cerebral ischemia

被引：51
|
作者：
Wenqi Chen [1 ]
Yinyi Sun [1 ]
Kangyong Liu [2 ]
Xiaojiang Sun [1 ]
机构：
[1] Department of Neurology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University
[2] Zhoupu Hospital
来源：
NeuralRegenerationResearch | 2014年 / 9卷 / 12期
基金：
中国国家自然科学基金;
关键词：
nerve regeneration; autophagy; lysosome; autophagosome; neuron; cerebral ischemia; signaling pathway; apoptosis; necrosis; survival; NSFC grant; neural regeneration;
D O I：
暂无
中图分类号：
R743.3 [急性脑血管疾病（中风）];
学科分类号：
1002 ;
摘要：
Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.
引用
收藏
页码：1210 / 1216
页数：7
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