Autophagy: a double-edged sword for neuronal survival after cerebral ischemia

被引：51

作者：

Wenqi Chen ^{[1
]}

Yinyi Sun ^{[1
]}

Kangyong Liu ^{[2
]}

Xiaojiang Sun ^{[1
]}

机构：

[1] Department of Neurology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University

[2] Zhoupu Hospital

来源：

NeuralRegenerationResearch | 2014年 / 9卷 / 12期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; autophagy; lysosome; autophagosome; neuron; cerebral ischemia; signaling pathway; apoptosis; necrosis; survival; NSFC grant; neural regeneration;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.

引用

页码：1210 / 1216

页数：7

共 50 条

[31] The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword
Chai, Peiwei
Ni, Hongyan
Zhang, He
Fan, Xianqun
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2016, 12 (11): : 1332 - 1340
[32] The Peroxisome-Autophagy Redox Connection: A Double-Edged Sword?
Li, Hongli
Lismont, Celien
Revenco, Iulia
Hussein, Mohamed A. F.
Costa, Claudio F.
Fransen, Marc
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
[33] Calcium: A double-edged sword
Wetzel, Randall C.
PEDIATRIC CRITICAL CARE MEDICINE, 2007, 8 (03) : 300 - 301
[34] The Multifaceted Role of Flavonoids in Cancer Therapy: Leveraging Autophagy with a Double-Edged Sword
Zhang, Zhe
Shi, Jiayan
Nice, Edouard C.
Huang, Canhua
Shi, Zheng
ANTIOXIDANTS, 2021, 10 (07)
[35] Natalizumab: A Double-Edged Sword?
DeAngelis, Lisa M.
ANNALS OF NEUROLOGY, 2009, 66 (03) : 262 - 263
[36] Rapamycin and Alzheimer disease: a double-edged sword?
Carosi, Julian M.
Sargeant, Timothy J.
AUTOPHAGY, 2019, 15 (08) : 1460 - 1462
[37] Autophagy in regulatory T cells: A double-edged sword in disease settings
Zhang, Jing
Chen, Longmin
Xiong, Fei
Zhang, Shu
Huang, Kun
Zhang, Ziyun
Wang, Cong-Yi
MOLECULAR IMMUNOLOGY, 2019, 109 : 43 - 50
[38] Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword
Zhang, Yunchao
Tang, Jiayu
Wang, Cheng
Zhang, Qinxiu
Zeng, Anqi
Song, Linjiang
GENES & DISEASES, 2024, 11 (01) : 367 - 381
[39] Autophagy in acute leukemias: A double-edged sword with important therapeutic implications
Evangelisti, Cecilia
Evangelisti, Camilla
Chiarini, Francesca
Lonetti, Annalisa
Buontempo, Francesca
Neri, Luca M.
McCubrey, James A.
Martelli, Alberto M.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2015, 1853 (01): : 14 - 26
[40] Viruses, apoptosis, and neuroinflammation—a double-edged sword
Peter G. E. Kennedy
Journal of NeuroVirology, 2015, 21 : 1 - 7

← 1 2 3 4 5 →