sS2-1 Possible involvement of hereditary factors in the risk modulation of arseniasis in two ethnic clans exposed to indoor combustion of high arsenic coal LIN Guo-Fang1, DU Hui2, CHEN Ji-Gang3, LU Hong-Chao2, GUO Wei-Chao1, ZHANG Xin-Jiang4, SHEN Jian-Hua1(1. Shanghai Institute for Biological Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China; 2. Prefecture Center for Disease Prevention and Control, Guiyang 562400, China; 3. Municipal Center for Disease Prevention and Control, Shanghai 200236, China; 4. Division of Dermatology, Affiliated Hospital, Zhengyi Medical College, Zhengyi 563003, China; E-mail: jh_shen@21cn.om)Abstract:A total of 2402 patients of arseniasis in a few villages in Southwest Guizhou Autonomous Prefecture, China, represents a unique case of endemic arseniasis related with indoor combustion of high arsenic coal. This study aimed to investigate the possible involvement of hereditary factors in the risk modulation of arseniasis in two clans of different ethnic origin living in one village for generations. A questionnaire-based study was performed in an ethnic Hmong clan P and a Han clan G1 in one village. The data was checked with the arseniasis case archives since 1980s. At the same time, arsenic concentrations in environmental samples (coal, indoor air, drinking water, corn and chili pepper that were baked over the stoves for desiccation) and in bio-specimens (urine and hair of members of both clans) were determined. Active efflux system of glutathione-conjugates of arsenic mediated by MRP1/ABCC1 may be an important route of arsenic detoxification in eukaryotes.
