The Current Situation on Major Depressive Disorder in China:Research on Mechanisms and Clinical Practice

被引：11

作者：

Zhenghua Hou ^{[1
]}

Wenhao Jiang ^{[1
]}

Yingying Yin ^{[1
]}

Zhijun Zhang ^{[2
]}

Yonggui Yuan ^{[1
]}

机构：

[1] Department of Psychosomatics and Psychiatry, Institute of Psychosomatic Medicine, Zhongda Hospital, Medical School of Southeast University

[2] Department of Neurology, Institute of Neuropsychiatry,Zhongda Hospital, Medical School of Southeast University

来源：

NeuroscienceBulletin | 2016年 / 32卷 / 04期

关键词：

Major depressive disorder; Epidemiology; Antidepressant; Pathogenesis; Biomarker; China;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

Depression is the most disabling disorder worldwide that accounts for the highest proportion of global burden attributable to mental disorders. Major depressive disorder（MDD） is characterized by deep sadness, reduced energy,vegetative nervous system dysregulation, cognitive dysfunction, and even a high suicidal tendency. Although other treatment choices are available, antidepressant medication is the front-line treatment option for MDD. Regarding clinical efficacy, only 50% of patients respond to frontline antidepressants, and <33% obtain remission. Currently, objective indexes to guide clinical decisions are still lacking. Furthermore, knowledge about the neurobiological mechanisms underlying discrepant antidepressant outcomes is still also fragmentary. In the present review, we discuss the current research progress and clinical opinions on MDD in China.

引用

页码：389 / 397

页数：9

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