α-Anordrin- induced　apoptosis　of　leukemia　K562　cells　is　not　prevented　by　cicloheximide

被引：1

作者：

楼丽广 ^{[1
]}

胥彬 ^{[1
]}

机构：

[1] 中国科学院上海药物研究所

来源：

ActaPharmacologicaSinica | 1997年 / 02期

关键词：

α-双炔失碳酯; 环己米特; 白血病K562; DNA损伤; 培养的肿瘤细胞;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

研究蛋白质合成抑制剂环己米特（ｃｉｃｌｏｈｅｘｉｍｉｄｅ，Ｃｉｃ）对α双炔失碳酯（αａｎｏｒｄｒｉｎ，Ａｎｏ）诱导的白血病Ｋ５６２细胞凋亡的影响．方法：荧光显微镜观察形态学变化；流式细胞仪检测ＤＮＡ含量；琼脂糖凝胶电泳分析ＤＮＡ断裂．结果：Ａｎｏ５０μｍｏｌ·Ｌ－１处理Ｋ５６２细胞２４小时诱导细胞凋亡．Ｃｉｃ１μｍｏｌ·Ｌ－１共同处理不能减弱或延缓Ａｎｏ的这一作用．相反，Ｃｉｃ明显增强Ａｎｏ诱导的细胞凋亡．Ｃｉｃ１００μｍｏｌ·Ｌ－１本身诱导２５％Ｋ５６２细胞凋亡．结论：Ａｎｏ诱导的Ｋ５６２细胞凋亡不依赖于新的蛋白质合成．

引用

页码：74 / 77

页数：4

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α-Anordrin- induced apoptosis of leukemia K562 cells is not prevented by cicloheximide

α-Anordrin- induced　apoptosis　of　leukemia　K562　cells　is　not　prevented　by　cicloheximide