We investigate relationships between the Moore-Penrose inverse(ABA*)and the product [(AB)(1,2,3)]*B(AB)(1,2,3)through some rank and inertia formulas for the difference of(ABA*)-[(AB)(1,2,3)]*B(AB)(1,2,3),where B is Hermitian matrix and(AB)(1,2,3)is a {1,2,3}-inverse of AB.We show that there always exists an(AB)(1,2,3)such that(ABA*)= [(AB)(1,2,3)]*B(AB)(1,2,3)holds.In addition,we also establish necessary and sufficient conditions for the two inequalities(ABA*) [(AB)(1,2,3)]*B(AB)(1,2,3)and(ABA*)[(AB)(1,2,3)]*B(AB)(1,2,3)to hold in the L¨owner partial ordering.Some variations of the equalities and inequalities are also presented.In particular,some equalities and inequalities for the Moore-Penrose inverse of the sum A + B of two Hermitian matrices A and B are established.