Role of androgen receptor in prostate cancer

被引：0
|
作者：
Hiroyoshi Suzuki
Haruo Ito
机构：
[1] Chiba 260-8670
[2] Chiba University School of Medicine I-8-I Inohana
[3] Chiba-shi
[4] Chuo-ku
[5] Department of Urology
[6] Japan
来源：
Asian Journal of Andrology | 1999年 / 03期
关键词：
androgen receptors; prostatic neoplasms; genetic change; methylation;
D O I：
暂无
中图分类号：
R737.25 [前列腺肿瘤];
学科分类号：
摘要：
The growth of prostate cancer is sensitive to androgen, and hormonal therapy has been used for treatment of ad-vanced cancer. About 80% of prostate cancers initially respond to hormonal therapy, howerver, more than half of the re-sponders gradually become resistant to this therapy. Changes in tumors from an androgen-responsive to an androgen-unre-sponsive state have been widely discussed. Since androgen action is mediated by androgen receptor (AR), abnormalitiesof AR is believed to play an important role of the loss of androgen responsiveness in prostate cancer. This article focusedon the role of AR in the progression of prostate cancer. (Asian J Androl 1999 Sep; 1: 81-85)
引用
收藏
页码：81 / 85
页数：5
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